KINNEAR D G, MACINTOSH P C, CAMERON D G, JOHNS D G, BURGEN A S
Can Med Assoc J. 1963 Nov 9;89(19):975-9.
The intestinal absorption of folic acid in patients with idiopathic steatorrhea was studied by the oral administration of tritium-labelled folic acid in a dosage of 15 mug./kg. Results were expressed as a percentage of the orally administered folic acid radioactivity excreted in the urine over 24 hours. The mean excretion of radioactivity in 38 normal subjects was 48.2 +/- 16.6% (mean +/- SD), whereas eight patients with untreated idiopathic steatorrhea excreted only 16.7 +/- 3.4% (mean +/- SE).The ability of the gluten-free diet to correct this absorptive defect was demonstrated by the finding of normal values in 11 patients in complete clinical remission for periods exceeding six months after institution of the diet. Serial studies in individual patients indicated that a significant improvement was obtainable in as short a period as two weeks following exclusion of gluten from the diet.
通过口服剂量为15微克/千克的氚标记叶酸，对特发性脂肪泻患者的叶酸肠道吸收情况进行了研究。结果以24小时尿液中排出的口服叶酸放射性占比来表示。38名正常受试者的放射性平均排泄率为48.2±16.6%（平均值±标准差），而8名未经治疗的特发性脂肪泻患者仅排泄了16.7±3.4%（平均值±标准误）。对于11名在采用无麸质饮食超过6个月后完全临床缓解的患者，其吸收值正常，这证明了无麸质饮食纠正这种吸收缺陷的能力。对个体患者的系列研究表明，在饮食中排除麸质后短短两周内即可取得显著改善。
