BRUNETTE M, GERBEAUX S
Can Med Assoc J. 1963 Nov 23;89(21):1074-83.
Several reports of idiopathic hypercalcemia of childhood have been published since Lightwood in 1932 described dwarfism associated with mental retardation, strabismus, hypercalcemia, nephrocalcinosis and osteosclerosis. The present paper adds two new cases. The first patient was 15 months old when first seen with stunted physical and mental growth, a systolic murmur, and a serum calcium value of 13 mg. %. This child suffered several severe infections and in spite of a low calcium intake and the administration of chelating agents her blood calcium rose until death six months later. The other patient, three years old, also had delayed physical and mental development, typical facies, a systolic murmur, skeletal lesions, and nephrocalcinosis. Varied therapeutic attempts failed. Idiopathic hypercalcemia of childhood is reviewed in the light of the 94 reports already published.
自1932年莱特伍德描述了与智力发育迟缓、斜视、高钙血症、肾钙质沉着症和骨硬化相关的侏儒症以来，已有多篇关于儿童特发性高钙血症的报道。本文新增了两例病例。首例患者初诊时15个月大，体格和智力发育迟缓，有收缩期杂音，血清钙值为13毫克%。该患儿遭受了几次严重感染，尽管钙摄入量低且使用了螯合剂，但血钙仍持续升高，直至6个月后死亡。另一例患者3岁，同样存在体格和智力发育迟缓、典型面容、收缩期杂音、骨骼病变和肾钙质沉着症。各种治疗尝试均告失败。根据已发表的94篇报道对儿童特发性高钙血症进行了综述。
