Zakrzewska J M, Patsalos P N
Institute of Dental Surgery, Eastman Dental Hospital, London, England.
Oral Surg Oral Med Oral Pathol. 1992 Oct;74(4):439-50. doi: 10.1016/0030-4220(92)90292-x.
Management of trigeminal neuralgia, a severe facial pain, remains difficult. All patients are initially treated with drugs. Since the seventeenth century more than 40 different preparations have been used; some of these, although effective, had toxic side effects. The most useful drugs at present are carbamazepine, phenytoin, baclofen, and clonazepam. A new drug, oxcarbazepine, is showing therapeutic promise. The most common reason for therapeutic failure with antineuralgic drugs is inadequate dosage. We review here the pharmacokinetics, side effects, possible drug interactions, plasma and serum therapeutic concentrations, and the available formulations of each drug. On the basis of these considerations and clinical reports describing the use of these drugs, we make dosage recommendations to enable the practitioner to individualize therapeutic regimens.
三叉神经痛是一种严重的面部疼痛，其治疗仍然困难。所有患者最初均采用药物治疗。自17世纪以来，已使用了40多种不同的制剂；其中一些虽然有效，但有副作用。目前最有用的药物是卡马西平、苯妥英钠、巴氯芬和氯硝西泮。一种新药奥卡西平显示出治疗前景。抗神经痛药物治疗失败的最常见原因是剂量不足。我们在此回顾每种药物的药代动力学、副作用、可能的药物相互作用、血浆和血清治疗浓度以及可用剂型。基于这些考虑因素以及描述这些药物使用情况的临床报告，我们给出剂量建议，以使从业者能够制定个体化的治疗方案。
