Mogensen P H, Jórgensen L, Boas J, Dam M, Vesterager A, Flesch G, Jensen P K
University Neurology Clinic, Hvidovre Hospital, Denmark.
Acta Neurol Scand. 1992 Jan;85(1):14-7.
The effects of dextropropoxyphene on the steady-state kinetics of oxcarbazepine and its metabolites were investigated in eight patients with epilepsy or trigeminal neuralgia. One patient dropped out of the study, presumably due to side-effects of dextropropoxyphene. Dextropropoxyphene did not affect the plasma levels of the principal active metabolite, 10,11-dihydro-10-hydroxy-carbamazepine. Since dextropropoxyphene is known to increase the plasma levels of carbamazepine, leading to toxicity, the findings of this study suggest that oxcarbazepine is a useful alternative to carbamazepine when concomitant dextropropoxyphene therapy is required.
在8例癫痫或三叉神经痛患者中研究了右丙氧芬对奥卡西平及其代谢产物稳态动力学的影响。1例患者退出研究，推测是由于右丙氧芬的副作用。右丙氧芬不影响主要活性代谢产物10,11-二氢-10-羟基卡马西平的血浆水平。由于已知右丙氧芬会增加卡马西平的血浆水平并导致毒性，本研究结果表明，当需要同时进行右丙氧芬治疗时，奥卡西平是卡马西平的一种有用替代药物。
