复发性阿弗他口炎患者中HLA - B51的密切关联。

Close association of HLA-B51 in persons with recurrent aphthous stomatitis.

作者信息

Shohat-Zabarski R, Kalderon S, Klein T, Weinberger A

机构信息

Department of Medicine B. Beilinson Medical Center, Petah Tikva, Israel.

出版信息

Oral Surg Oral Med Oral Pathol. 1992 Oct;74(4):455-8. doi: 10.1016/0030-4220(92)90294-z.

DOI:10.1016/0030-4220(92)90294-z

PMID:1408019

Abstract

The HLA typing profile of 26 Israeli subjects with recurrent aphthous stomatitis (RAS) was examined and compared with that of 100 healthy control subjects. HLA-B51 was found in six subjects (23%) with RAS and in nine control subjects (9%) (p < 0.05). HLA-Cw7 was found in six subjects with RAS (23%) and in five control subjects (5%) (p < 0.01). Eleven subjects had first-degree relatives who had RAS. Because a high frequency of HLA-B51 has been found in Behcet's syndrome and aphthous stomatitis is part of this syndrome, it is suggested that in some subjects with RAS the entire syndrome may actually develop in the future.

摘要

对26名患有复发性阿弗他口炎（RAS）的以色列受试者的HLA分型进行了检测，并与100名健康对照受试者的HLA分型进行了比较。在6名（23%）患有RAS的受试者中发现了HLA - B51，在9名对照受试者中（9%）也发现了该型（p < 0.05）。在6名（23%）患有RAS的受试者中发现了HLA - Cw7，在5名对照受试者中（5%）发现了该型（p < 0.01）。11名受试者有患RAS的一级亲属。由于在白塞病中已发现HLA - B51的高频率存在，且阿弗他口炎是该综合征的一部分，因此有人提出，在一些患有RAS的受试者中，整个综合征可能在未来实际发生。