Gallina G, Cumbo V, Messina P, Caruso C
Oral Surg Oral Med Oral Pathol. 1985 Apr;59(4):364-70. doi: 10.1016/0030-4220(85)90061-1.
In this report we have investigated the frequencies of HLA-A, B, C, DR, MT, and MB markers in 26 Sicilian subjects affected by recurrent aphthous stomatitis (RAS) and in 84 healthy controls. Our data show that the frequency of HLA-DR7 antigen is significantly increased in RAS-affected persons (61.5% versus 21.4%; pc less than 0.0025), whereas the B5 antigen frequency is decreased significantly (absent in patients versus 27.3% in controls; pc = 0.04). Thus, present results suggest that HLA-linked genetic factors may play a role in the development of RAS.
在本报告中，我们调查了26名患有复发性阿弗他口炎（RAS）的西西里受试者以及84名健康对照者中HLA - A、B、C、DR、MT和MB标记物的频率。我们的数据显示，HLA - DR7抗原在RAS患者中的频率显著增加（61.5%对21.4%；p值小于0.0025），而B5抗原频率则显著降低（患者中不存在，对照者中为27.3%；p值 = 0.04）。因此，目前的结果表明，与HLA相关的遗传因素可能在RAS的发病过程中起作用。
