Pávics L, Ambrus E, Katona E, Barzó P, Morvay Z, Csernay L
Szent-Györgyi Albert Orvostudományi Egyetem, Központi Izotópdiagnosztikai Laboratórium, Szeged.
Orv Hetil. 1992 Sep 27;133(39):2495-500.
In 28 (3 normal, 11 TIA, 14 completed stroke) patients 99mTc-HMPAO rCBF SPECT studies were performed at rest and after acetazolamide administration. For the investigations, a one-day protocol (the stress study directly followed the rest investigation) was used. The reconstructed and normalized slices were evaluated visually and semiquantitatively with a side difference analysis method. In the group of TIA patients, the abnormal results of the rCBF investigations increased from 55% to 82% after acetazolamide provocation. The corresponding results in the completed stroke group were 80% and 87%. After acetazolamide stimulation, hypoperfusion appeared or become more pronounced in the majority of the TIA group patients in contrast with the completed stroke patients with an unchanged or decreased perfusion abnormality. The semiquantitative evaluation method was mostly effective in the TIA group, where predominantly a one-sided cerebrovascular disorder was suspected. It was concluded that the 99mTc-HMPAO studies allow demonstration of the acetazolamide-induced cerebral perfusion alterations, and this method can be useful in the diagnosis and management of cerebrovascular disorders.
对28例患者（3例正常，11例短暂性脑缺血发作，14例完全性卒中）进行了静息状态及乙酰唑胺给药后的99mTc-HMPAO脑血流灌注单光子发射计算机断层扫描（SPECT）研究。研究采用一日方案（负荷研究紧接静息研究之后进行）。对重建并归一化的层面进行视觉评估，并采用双侧差异分析方法进行半定量评估。在短暂性脑缺血发作患者组中，乙酰唑胺激发后，脑血流灌注研究异常结果从55%增至82%。完全性卒中组的相应结果分别为80%和87%。与灌注异常未改变或减轻的完全性卒中患者相比，乙酰唑胺刺激后，大多数短暂性脑缺血发作组患者出现灌注减低或灌注减低更明显。半定量评估方法在短暂性脑缺血发作组大多有效，该组主要怀疑存在单侧脑血管疾病。得出的结论是，99mTc-HMPAO研究能够显示乙酰唑胺诱导的脑灌注改变，且该方法在脑血管疾病的诊断和管理中可能有用。
