Dunaev V V, Butov V I
Farmakol Toksikol. 1976 May-Jun;39(3):312-6.
On a model of transplantable albeolar-mucous RS cancer it is shown that hydrocortisone, desoxycorticosteonre-acetate (DOCA), cyanocobalamine used in combination with folic and nicotinic acids does not lower the cytostatic activity of thiophosphamide and in a number cases even potentiates its action. A relation between changes occurring under the influence of the chemical agents on the energy exchange (a fall of the lactate level) and the linked with it transfer of ions (reduced concentration of magnesium, calcium and a rise in the level of sodium) through the membranes of cancer cells was revealed. Against the background of chemotherapy gycolytic processes in the malignant cells. Evidence was brought to bear that under the influence of thiophosphamide the response of the neoplastic tissue to DOCA becomes perverted (the concentration of potassium goes up and the level of sodium delcines).
在可移植的肺泡 - 黏液性网状细胞肉瘤癌症模型中表明，氢化可的松、醋酸脱氧皮质酮（DOCA）、氰钴胺与叶酸和烟酸联合使用时，不会降低硫代磷酰胺的细胞抑制活性，在一些情况下甚至会增强其作用。揭示了化学试剂影响下癌细胞能量代谢变化（乳酸水平下降）及其伴随的离子跨膜转运（镁、钙浓度降低，钠水平升高）之间的关系。在化疗背景下，恶性细胞中糖酵解过程出现变化。有证据表明，在硫代磷酰胺的影响下，肿瘤组织对DOCA的反应发生了改变（钾浓度升高，钠水平下降）。
