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类癌综合征中的垂体-性腺功能:对氯苯丙氨酸治疗的影响

Pituitary-gonadal function in the carcinoid syndrome: effect of parachlorophynylalanine therapy.

作者信息

Feldman J M, Plonk J W

出版信息

Horm Metab Res. 1977 Mar;9(2):156-60. doi: 10.1055/s-0028-1093567.

DOI:10.1055/s-0028-1093567
PMID:140843
Abstract

Six patients with the carcinoid syndrome (C.S) had serum luteinizing hormone (LH) concentrations that were greater than age and sex matched control subjects. The serum follicle stimulating hormone (FSH) and testosterone concentrations of the groups did not differ. Four of the 5 C.S. patients tested had an increase in serum testosterone after human chorionic gonadotropin administration and 5 of the 5 subjects tested had an increase in serum LH after clomiphene citrate administration. One of the 4 subjects treated with the tryptophan hydroxylase inhibitor parachlorophenylalanine (PCPA) had a reduction in serum testosterone. He was also receiving methysergide. The other 3 subjects treated with PCPA did not have any persistent alterations in serum testosterone.

摘要

6例类癌综合征(C.S)患者的血清促黄体生成素(LH)浓度高于年龄和性别匹配的对照受试者。两组的血清促卵泡生成素(FSH)和睾酮浓度无差异。5例接受检测的C.S.患者中有4例在注射人绒毛膜促性腺激素后血清睾酮升高,5例接受检测的受试者中有5例在服用枸橼酸氯米芬后血清LH升高。4例接受色氨酸羟化酶抑制剂对氯苯丙氨酸(PCPA)治疗的受试者中有1例血清睾酮降低。他同时还在服用麦角新碱。其他3例接受PCPA治疗的受试者血清睾酮没有持续变化。

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