Dawood M Y, Saxena B B
Obstet Gynecol. 1978 Oct;52(4):445-50.
Plasma follicle stimulating hormone (FSH) and luteinizing hormone (LH), prolactin (PRL), estradiol (E2), progesterone (P), testosterone (T), and dihydrotestosterone (DHT) were measured by radioimmunoassay in 7 patients who had ovulation induction with clomiphene citrate and human chorionic gonadotropin. Six of the 7 patients ovulated. There was higher increase in FSH than LH in 3 patients who also showed a midcycle FSH and LH peak. Plasma PRL was initially elevated in 2 patients, remained normal (less than 25 ng/ml) throughout the cycle in one patient, and showed an increase in the late luteal phase in 3 patients. Plasma E2 showed a good response at the end of clomiphene intake, with a subsequent preovulatory surge. Plasma P increased to more than 25 ng/ml in patients who ovulated and reached higher levels than in normal ovulatory cycles. Plasma T increased and decreased in a similar pattern to plasma E2 and was higher with clomiphene therapy than in the normal menstrual cycle. Plasma DHT remained similar to concentrations found in normal menstrual cycles. The findings are discussed in relation to the effect of clomiphene and these hormones on the pituitary-ovarian axis, ovulation rate, and conception rate.
采用放射免疫分析法对7例接受枸橼酸氯米芬和人绒毛膜促性腺激素促排卵治疗的患者测定血浆促卵泡生成素（FSH）、促黄体生成素（LH）、催乳素（PRL）、雌二醇（E2）、孕酮（P）、睾酮（T）和双氢睾酮（DHT）。7例患者中有6例排卵。3例同时出现月经周期中期FSH和LH峰值的患者，FSH升高幅度高于LH。2例患者血浆PRL最初升高，1例患者整个周期均保持正常（低于25 ng/ml），3例患者在黄体晚期出现升高。血浆E2在服用氯米芬结束时显示出良好反应，随后出现排卵前高峰。排卵患者血浆P升高至超过25 ng/ml，且达到高于正常排卵周期的水平。血浆T的升高和降低模式与血浆E2相似，且氯米芬治疗时高于正常月经周期。血浆DHT浓度与正常月经周期相似。结合氯米芬及这些激素对垂体-卵巢轴、排卵率和受孕率的影响对这些发现进行了讨论。
