Venkataraman P S, Ahluwalia B W
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City 73190.
Pediatrics. 1992 Nov;90(5):767-70.
Measurement of total body bone mineral content and body composition has not previously been convenient in the newborn. X-ray densitometry, otherwise known as dual-energy x-ray absorptiometry (DEXA), has been used in adults to assess with accuracy and precision the total body mineral content, lean mass, and fat. Body composition measurements were determined in vivo by DEXA in term newborns, and they were compared with values reported by chemical analysis of the cadaver, with skin-fold thickness measurements, and with bone mineral content measured by single photon absorptiometry. The intermeasurement coefficient of variation was < or = 2.5% for bone mineral content, and < or = 1% for fat and lean mass. The values for bone mineral content, fat, and lean mass fall within the ranges expected based on the reported values measured by chemical analysis of the infant cadaver. Triceps and quadriceps skin-fold measurements were best correlated with total body fat as measured by DEXA. The bone mineral content of the distal third radius site as measured by single photon absorptiometry in newborns showed significant correlation with total body bone mineral content. DEXA provides a reproducible and convenient method for the determination of body composition in newborns.
以往，新生儿全身骨矿物质含量和身体成分的测量并不方便。X射线密度测定法，也就是双能X射线吸收法（DEXA），已用于成人，以准确且精确地评估全身矿物质含量、瘦体重和脂肪。通过DEXA对足月儿进行了体内身体成分测量，并将其与尸体化学分析报告的值、皮褶厚度测量值以及单光子吸收法测量的骨矿物质含量进行了比较。骨矿物质含量的测量间变异系数≤2.5%，脂肪和瘦体重的测量间变异系数≤1%。骨矿物质含量、脂肪和瘦体重的值落在基于婴儿尸体化学分析报告值预期的范围内。肱三头肌和股四头肌皮褶测量值与通过DEXA测量的全身脂肪相关性最好。新生儿单光子吸收法测量的桡骨远端三分之一部位的骨矿物质含量与全身骨矿物质含量显著相关。DEXA为新生儿身体成分的测定提供了一种可重复且方便的方法。
