Hart P D, Wilkie M E, Edwards A, Cunningham J
Department of Nephrology, Royal London Hospital, UK.
Eur J Clin Nutr. 1993 May;47(5):347-52.
Traditional methods for estimating total body fat rely on the assumption that body fat distribution and bone mineral content are constant. However, in patients undergoing renal transplantation rapid changes in body composition occur, with variations in fat distribution and bone mineral content. In order to determine the reliability of skinfold measurement (SFM) in these patients, we compared it with dual energy X-ray absorptiometry (DEXA), which estimates body composition without reliance on assumptions of constant fat distribution and bone mineral content. Thirty-four adult renal transplant recipients were studied at the time of transplantation and again after 3 and 6 months. The correlation coefficients of DEXA vs SFM at the three time points were 0.84, 0.78, 0.85, respectively (P = 0.0001). In 34 healthy adults serving as controls, the correlation coefficient was 0.95 (P = 0.0001). Total body fat increased progressively following renal transplantation (P < 0.03 by 6 months) with SFM showing considerable disagreement with DEXA measurements of percentage total body fat. Thus skinfold measurements underestimated changes in total body fat following renal transplantation, especially in those gaining substantial amounts of body fat, and DEXA appeared to be a more appropriate technique.
传统的估计全身脂肪的方法依赖于身体脂肪分布和骨矿物质含量恒定的假设。然而，肾移植患者的身体成分会迅速发生变化，脂肪分布和骨矿物质含量也会有所不同。为了确定皮褶厚度测量（SFM）在这些患者中的可靠性，我们将其与双能X线吸收法（DEXA）进行了比较，DEXA在估计身体成分时不依赖于脂肪分布和骨矿物质含量恒定的假设。对34名成年肾移植受者在移植时以及移植后3个月和6个月再次进行了研究。三个时间点DEXA与SFM的相关系数分别为0.84、0.78、0.85（P = 0.0001）。在作为对照的34名健康成年人中，相关系数为0.95（P = 0.0001）。肾移植后全身脂肪逐渐增加（6个月时P < 0.03），SFM显示与DEXA测量的全身脂肪百分比存在相当大的差异。因此，皮褶厚度测量低估了肾移植后全身脂肪的变化，尤其是在那些体重增加较多的患者中，DEXA似乎是一种更合适的技术。
