[Study of circadian rhythm of bronchial patency for timely correction and evaluation of the effectiveness of inhalation powder forms of salbutamol in children with bronchial asthma].

A study was made of the circadian rhythms of bronchial patency for ++timely correction and dynamic estimation of the efficacy of powdered inhalation salbutamol (ventodisc) in 30 children aged 7-15 years suffering from persistent recurrent bronchial asthma. The treatment with ventodisc was carried out after basic therapy (euphylline or theopec and/or becotid). During 1 week the children inhaled the drug only at the moments of attacks of obstructed respiration. Starting from the 2nd week of the study ventodisc was applied prophylactically bearing in mind the rhythm of the bronchial tone in hours of minimal values of the maximal volumetric rate of expiration (MVRexp). It has been revealed that an optimal approach to ventodisc administration consists in a preventive drug intake arresting asphyxia attacks, inasmuch children with low values of external respiratory function (particularly in cases where MVRexp is less than 50% of normal) during bronchial asthma attacks are not capable of activating the spraying device and taking the whole drug dose. The use of ventodisc in the chronocorrection mode ameliorated the circadian rhythm of the bronchial tone and minimized the drug requirement 2.3-fold.