Nucleotide sequence of the intron of the germline human kappa immunoglobulin gene connecting the J and C regions reveals a matrix association region (MAR) next to the enhancer.
作者信息
Whitehurst C, Henney H R, Max E E, Schroeder H W, Stüber F, Siminovitch K A, Garrard W T
机构信息
Department of Biochemistry, UT Southwestern Medical Center, Dallas 75235.
出版信息
Nucleic Acids Res. 1992 Sep 25;20(18):4929-30. doi: 10.1093/nar/20.18.4929.
Abstract
摘要
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Nucleotide sequence of the intron of the germline human kappa immunoglobulin gene connecting the J and C regions reveals a matrix association region (MAR) next to the enhancer.连接人类种系κ免疫球蛋白基因J区和C区的内含子的核苷酸序列显示，增强子旁存在一个基质附着区域（MAR）。
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本文引用的文献
1
Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments.克隆的人类和小鼠κ免疫球蛋白恒定区和J区基因在功能片段上保持同源性。
Cell. 1980 Nov;22(1 Pt 1):197-207. doi: 10.1016/0092-8674(80)90168-3.
2
A conserved sequence in the immunoglobulin J kappa-C kappa intron: possible enhancer element.免疫球蛋白Jκ-Cκ内含子中的一个保守序列：可能的增强子元件。
Nature. 1983;304(5925):447-9. doi: 10.1038/304447a0.
3
Evolution of human immunoglobulin kappa J region genes.人类免疫球蛋白κ J 区基因的进化
J Biol Chem. 1982 Feb 10;257(3):1516-22.
4
The human CK gene segment and the kappa deleting element are closely linked.人类CK基因片段与κ缺失元件紧密相连。
Nucleic Acids Res. 1986 Jun 11;14(11):4591-603. doi: 10.1093/nar/14.11.4591.
5
The enhancer of the immunoglobulin heavy chain locus is flanked by presumptive chromosomal loop anchorage elements.免疫球蛋白重链基因座的增强子两侧是假定的染色体环锚定元件。
J Biol Chem. 1987 Apr 15;262(11):5394-7.
6
Cohabitation of scaffold binding regions with upstream/enhancer elements of three developmentally regulated genes of D. melanogaster.果蝇三个发育调控基因的支架结合区域与上游/增强子元件的共定位。
Cell. 1986 Aug 15;46(4):521-30. doi: 10.1016/0092-8674(86)90877-9.
7
Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites.κ免疫球蛋白基因的染色体环锚定发生在增强子旁边一个含有拓扑异构酶II位点的区域。
Cell. 1986 Jan 31;44(2):273-82. doi: 10.1016/0092-8674(86)90761-0.
8
Dysfunction of chromosomal loop attachment sites: illegitimate recombination linked to matrix association regions and topoisomerase II.染色体环附着位点功能障碍：与基质附着区域和拓扑异构酶II相关的异常重组
Proc Natl Acad Sci U S A. 1989 Jul;86(14):5497-501. doi: 10.1073/pnas.86.14.5497.
9
Immunoglobulin kappa gene expression after stable integration. II. Role of the intronic MAR and enhancer in transgenic mice.稳定整合后的免疫球蛋白κ基因表达。II. 内含子MAR和增强子在转基因小鼠中的作用。
J Biol Chem. 1989 Dec 15;264(35):21190-5.
10
Immunoglobulin kappa gene expression after stable integration. I. Role of the intronic MAR and enhancer in plasmacytoma cells.稳定整合后免疫球蛋白κ基因的表达。I. 内含子MAR和增强子在浆细胞瘤细胞中的作用。
J Biol Chem. 1989 Dec 15;264(35):21183-9.
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