De Benedictis G, Ricco R, Lettini T, Serio G, Pennella A, Troia M, Napoli A, Pesce Delfino V
Institute of Pathological Anatomy, University of Bari, Italy.
Pathol Res Pract. 1992 Jun;188(4-5):576-80. doi: 10.1016/S0344-0338(11)80059-2.
In order to characterize medulloblastomas and to get over the difficulties sometimes encountered in differential diagnosis, a double morphometric procedure has been applied to its nuclei. The first consisted of size measurements (maximum diameter, area and perimeter), the latter is represented by S.A.M. (Shape Analytical Morphometry) software-system specifically implemented to describe shape of biological structure by analytical parameters. Analytical and dimensional parameters submitted to Hotelling's multivariate discriminant analysis gave the best results when used together in convenient discriminant subsets, thereby allowing a good distinction between medulloblastoma in comparison with neuroblastoma, Ewing's tumor, lymphoblastic and lymphocytic lymphoma. These results underline the usefulness of morphometric characterization also for practical diagnostic purposes.
为了对髓母细胞瘤进行特征描述并克服有时在鉴别诊断中遇到的困难，已对其细胞核应用了双重形态测量程序。第一种方法是进行大小测量（最大直径、面积和周长），第二种方法由专门为通过分析参数描述生物结构形状而实现的S.A.M.（形状分析形态测量法）软件系统来表示。当将分析参数和尺寸参数一起用于方便的判别子集中时，提交给霍特林多元判别分析的这些参数能产生最佳结果，从而能够很好地区分髓母细胞瘤与神经母细胞瘤、尤因肉瘤、淋巴细胞性和淋巴母细胞性淋巴瘤。这些结果强调了形态测量特征描述对于实际诊断目的的有用性。
