急性淋巴细胞白血病（A.L.L.）中的手镜（HM）细胞。使用S.A.M.（形状分析形态计量学）系统通过形态计量分析参数进行细胞分类的尝试。

Hand-mirror (HM) cells in acute lymphoblastic leukaemia (A.L.L.). An attempt at cellular classification by morphometric analytical parameters using the S.A.M. (Shape Analytical Morphometry) system.

作者信息

Ricco R, Liso V, Specchia G, Pavone V, Marzano N, Lettini T, Pesce Delfino V, Pennella A

机构信息

Institute of Pathological Anatomy, Haematology, University of Bari, Italy.

出版信息

Pathol Res Pract. 1989 Nov;185(5):715-8. doi: 10.1016/S0344-0338(89)80224-9.

DOI:10.1016/S0344-0338(89)80224-9

PMID:2696950

Abstract

A morphometric study of the nuclear and cytoplasmic shape of a blastic population in a case of HM-A.L.L. was performed by comparing the two differently shaped populations with and without HM configuration. The results obtained using analytical size-independent parameters created by the S.A.M. work-station enable us to characterize the shape of both blastic cell populations quantitatively, and strongly suggest the existence of shape modulation from one cellular type toward the other. Thus a possible sequence from blastic cells (having regular, rather round nuclei) to HM cells (characterized by high distortion of both nucleus and cytoplasm) was proposed.

摘要

对一例HM - A.L.L. 患者的母细胞群体的细胞核和细胞质形态进行了形态计量学研究，通过比较具有和不具有HM构型的两种不同形状的群体来进行。使用S.A.M. 工作站创建的与大小无关的分析参数获得的结果，使我们能够定量地表征两种母细胞群体的形状，并有力地表明存在从一种细胞类型向另一种细胞类型的形状调节。因此，提出了从母细胞（具有规则的、相当圆的细胞核）到HM细胞（以细胞核和细胞质的高度变形为特征）的可能序列。