腺苷类似物与吗啡在镇痛试验中的相互作用。
Interaction of adenosine analogs with morphine in analgesic tests.
作者信息
Malec D, Michalska E
机构信息
Department of Pharmacodynamics, Medical Academy, Lublin, Poland.
出版信息
Pol J Pharmacol Pharm. 1992 Mar-Apr;44(2):121-33.
The effect of selective adenosine receptor agonists on nociceptive responses of mice and rats and on morphine analgesia was investigated. All compounds used: phenylisopropyladenosine (R-PIA), adenosine ethylcarboxamide (NECA), cyclohexyladenosine (CHA) and 2-chloroadenosine (2-CADO) exhibited antinociceptive action in mice and rats in the hot-plate (56 degrees C) and tail-immersion (52 degrees C) tests. R-PIA, CHA and NECA potentiated the antinociceptive action of morphine in mice, and R-PIA and NECA--in rats. 2-CADO did not affect the morphine action in the tests.
研究了选择性腺苷受体激动剂对小鼠和大鼠伤害性反应以及对吗啡镇痛作用的影响。所使用的所有化合物：苯异丙基腺苷（R-PIA）、腺苷乙羧胺（NECA）、环己基腺苷（CHA）和2-氯腺苷（2-CADO），在热板（56摄氏度）和尾部浸入（52摄氏度）试验中，均在小鼠和大鼠身上表现出抗伤害作用。R-PIA、CHA和NECA增强了吗啡对小鼠的抗伤害作用，R-PIA和NECA增强了对大鼠的抗伤害作用。在试验中，2-CADO不影响吗啡的作用。
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