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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Contreras E, Germany A, Villar M

Departamento de Ciencias Fisiológicas, Facultad de Ciencias Biológicas y de Recursos Naturales, Universidad de Concepción, Chile.

Gen Pharmacol. 1990;21(5):763-7. doi: 10.1016/0306-3623(90)91031-l.

The analogs of adenosine D- and L-phenylisopropyladenosine (D- and L-PIA) and chloroadenosine (CADO) induced analgesia in mice (hot-plate test). 2. The antinociceptive effects of the three adenosine agonists were antagonized by caffeine but were unaffected by naloxone. 3. Morphine-induced antinociception was increased by pretreatment with adenosine agonists. 4. Whereas CADO significantly attenuated the induction of morphine tolerance, D- and L-PIA did not affect the process.

腺苷类似物D-和L-苯异丙基腺苷（D-和L-PIA）以及氯腺苷（CADO）在小鼠中诱导产生镇痛作用（热板试验）。2. 三种腺苷激动剂的抗伤害感受作用被咖啡因拮抗，但不受纳洛酮影响。3. 用腺苷激动剂预处理可增强吗啡诱导的抗伤害感受作用。4. 虽然CADO显著减弱吗啡耐受性的诱导，但D-和L-PIA不影响该过程。

Contreras E, Germany A, Villar M

Departamento de Ciencias Fisiológicas, Facultad de Ciencias Biológicas y de Recursos Naturales, Universidad de Concepción, Chile.

Gen Pharmacol. 1990;21(5):763-7. doi: 10.1016/0306-3623(90)91031-l.

The analogs of adenosine D- and L-phenylisopropyladenosine (D- and L-PIA) and chloroadenosine (CADO) induced analgesia in mice (hot-plate test). 2. The antinociceptive effects of the three adenosine agonists were antagonized by caffeine but were unaffected by naloxone. 3. Morphine-induced antinociception was increased by pretreatment with adenosine agonists. 4. Whereas CADO significantly attenuated the induction of morphine tolerance, D- and L-PIA did not affect the process.

腺苷类似物D-和L-苯异丙基腺苷（D-和L-PIA）以及氯腺苷（CADO）在小鼠中诱导产生镇痛作用（热板试验）。2. 三种腺苷激动剂的抗伤害感受作用被咖啡因拮抗，但不受纳洛酮影响。3. 用腺苷激动剂预处理可增强吗啡诱导的抗伤害感受作用。4. 虽然CADO显著减弱吗啡耐受性的诱导，但D-和L-PIA不影响该过程。