Sobel B E
Cardiovascular Division, Washington University School of Medicine, St. Louis, MO 63110.
Postgrad Med J. 1992;68 Suppl 1:S24-8.
Because of its quantitative power and capacity to image biochemically unaltered tracers of physiological substrates, cardiac positron-emission tomography has emerged as a promising diagnostic modality and a powerful clinical research tool. It has enhanced characterization of the efficacy of diverse interventions designed to improve myocardial perfusion, differentiation of reversibly from irreversibly injured ischaemic myocardium, and detection of cardiomyopathic states. Progress in high rates of data acquisition, improved spatial and temporal resolution, accelerated image processing, and 3-dimensional display of images of myocardium offer promise for widespread applications to early detection of cardiac allograft rejection, graft atherosclerosis, and the efficacy of pharmacological interventions designed to protect recipients of cardiac allografts.
由于其具备定量能力以及对生理底物的生物化学未改变示踪剂进行成像的能力，心脏正电子发射断层扫描已成为一种很有前景的诊断方式和强大的临床研究工具。它增强了对旨在改善心肌灌注的各种干预措施疗效的特征描述、可逆性与不可逆性损伤缺血心肌的区分，以及心肌病状态的检测。在高数据采集率、改进的空间和时间分辨率、加速图像处理以及心肌图像的三维显示方面取得的进展，为广泛应用于心脏同种异体移植排斥反应的早期检测、移植物动脉粥样硬化以及旨在保护心脏同种异体移植受者的药物干预措施的疗效提供了希望。
