单独使用及与甲氧苄啶联合使用时，舒苯咪唑对肠道病原体的体外活性。
In vitro activity of sulphimidazole alone and in association with trimethoprim against enteric pathogens.
作者信息
Castelli M, Baggio G, Ruberto A I, Rossi T, Provvisionato A, Malagoli M, Bossa R, Galatulas I
机构信息
Institute of Pharmacology, University of Modena, Italy.
出版信息
Pharmacol Res. 1992 May-Jun;25(4):373-81. doi: 10.1016/1043-6618(92)90674-z.
Sulphimidazole is a new sulphonamide belonging to the class of intestinal sulphonamides and characterized by the fact that it is active even in vitro. It has the heterocyclic ring of 5-nitroimidazoles on amidic nitrogen. Its antibacterial activity is similar to that of the classical sulphonamides but differs in that it also combats certain anaerobic bacteria such as Clostridium botulinum. This effect is completely absent in the case of sulphadiazine and sulphamethoxazole. Also, since p-amino-benzene-sulphonamide is present in the molecule, the drug acts in synergism with trimethoprim against certain aerobic or facultative strains of enteric pathogens.
磺胺咪唑是一种新型磺胺类药物，属于肠道磺胺类，其特点是即使在体外也具有活性。它在酰胺氮上有5-硝基咪唑的杂环。其抗菌活性与经典磺胺类药物相似，但不同之处在于它还能对抗某些厌氧菌，如肉毒梭菌。磺胺嘧啶和磺胺甲恶唑则完全没有这种作用。此外，由于分子中存在对氨基苯磺酰胺，该药物与甲氧苄啶协同作用，对某些需氧或兼性肠道病原菌菌株有效。
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