复方新诺明体外抗菌作用的重新评估。
A reappraisal of the antibacterial action of cotrimoxazole in vitro.
作者信息
Lewis E L, Anderson J D, Lacey R W
出版信息
J Clin Pathol. 1974 Feb;27(2):87-91. doi: 10.1136/jcp.27.2.87.
Abstract
The in-vitro action of the sulphamethoxazole/trimethoprim combination (cotrimoxazole) against coliforms, Proteus spp, and Staphylococcus aureus was re-examined. In nutrient broth the components of cotrimoxazole did not produce bacteriostatic synergy against most sulphonamide-resistant and a significant proportion of sulphonamide-sensitive strains. Any bactericidal action appeared to be due to the trimethoprim component. After addition to urine the combination was only bacteriostatic against most coliforms and Proteus spp over six hours. Further clinical trials are needed to determine the circumstances under which cotrimoxazole is superior to either trimethoprim or sulphonamides against some infections, particularly of the urinary tract.
摘要
重新检验了磺胺甲恶唑/甲氧苄啶合剂（复方新诺明）对大肠埃希菌、变形杆菌属和金黄色葡萄球菌的体外抗菌作用。在营养肉汤中，复方新诺明的成分对大多数耐磺胺类药物以及相当一部分对磺胺类药物敏感的菌株没有产生抑菌协同作用。任何杀菌作用似乎都归因于甲氧苄啶成分。加入尿液后，该合剂在6小时内仅对大多数大肠埃希菌和变形杆菌属有抑菌作用。需要进一步的临床试验来确定在哪些情况下，复方新诺明在治疗某些感染，特别是尿路感染方面优于甲氧苄啶或磺胺类药物。
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本文引用的文献
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Trimethoprim: laboratory and clinical studies.甲氧苄啶：实验室研究与临床研究
J Clin Pathol. 1968 Mar;21(2):202-9. doi: 10.1136/jcp.21.2.202.
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Combined antibacterial action in vitro of trimethoprim and sulphonamides. The in vitro nature of synergy.甲氧苄啶与磺胺类药物的体外联合抗菌作用。协同作用的体外性质。
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Present significance of resistance to trimethoprim and sulphonamides in coliforms, Staphylococcus aureus, and Streptococcus faecalis.大肠菌群、金黄色葡萄球菌和粪肠球菌对甲氧苄啶和磺胺类药物耐药性的当前意义。
J Clin Pathol. 1973 Mar;26(3):175-80. doi: 10.1136/jcp.26.3.175.
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Double-blind trial to compare ampicillin, cephalexin, co-trimoxazole, and trimethoprim in treatment of urinary infection.比较氨苄西林、头孢氨苄、复方新诺明和甲氧苄啶治疗尿路感染的双盲试验。
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Trimethoprim resistance determined by R factors.由R因子决定的甲氧苄啶耐药性。
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