Tonini M, Gatti G, Manzo L, Olibet G, Coccini T, Perucca E
Department of Internal Medicine and Therapeutics, University of Pavia, Italy.
Pharmacol Res. 1992 Sep;26(2):201-5. doi: 10.1016/s1043-6618(05)80133-1.
The antiepileptic drug vigabatrin (GVG) is known to decrease significantly the serum concentration of concurrently administered phenytoin (PHT) in epileptic patients. To assess a possible mechanism for this interaction, the effect of GVG on the intestinal absorption of PHT was investigated by means of circulation experiments in an in situ rat duodeno-jejunal loop. GVG did not affect the rate of disappearance of PHT from the loop perfusing medium, providing evidence against occurrence of GVG-induced impairment of PHT absorption.
