Liegeois-Chauvel C, Marquis P, Gisselbrecht D, Pantieri R, Beaumont D, Chauvel P
INSERM, Centre Paul Broca, St. Anne Hospital, Paris, France.
Epilepsia. 1989;30 Suppl 3:S23-5. doi: 10.1111/j.1528-1157.1989.tb05829.x.
Vigabatrin (gamma vinyl GABA, GVG) has been shown to be an effective antiepileptic agent. GVG specifically and irreversibly inhibits GABA-transaminase (GABA-T). Long-term animal toxicology studies have demonstrated that GVG can induce nonprogressive, reversible intramyelinic edema in central white matter tracts. The response to GVG varies among species, with rodents being the most dramatic and monkeys showing an equivocal effect even at high doses. The response in dogs is marked and measurable. The detection of these subtle findings requires the use of sophisticated technology. Evoked potentials are becoming reliable and sensitive tools in clinical neurology. This study, involving 54 patients for 11 months, was undertaken to assess the effect and safety of GVG in humans with refractory epilepsy. No data from this investigation indicate prolongation of neuronal conduction time in CNS pathways, suggesting that this agent is safe in humans.
氨己烯酸（γ-乙烯基氨基丁酸，GVG）已被证明是一种有效的抗癫痫药物。GVG能特异性且不可逆地抑制γ-氨基丁酸转氨酶（GABA-T）。长期动物毒理学研究表明，GVG可在中枢白质束中诱导非进行性、可逆的髓鞘内水肿。不同物种对GVG的反应有所不同，啮齿动物的反应最为显著，而猴子即使在高剂量时也表现出不明确的效果。犬类的反应明显且可测量。检测这些细微发现需要使用精密技术。诱发电位正成为临床神经学中可靠且灵敏的工具。这项为期11个月、涉及54名患者的研究旨在评估GVG对难治性癫痫患者的疗效和安全性。该调查没有数据表明中枢神经系统通路中神经元传导时间延长，这表明该药物对人类是安全的。
