Chopra J S, Sawhney B B, Chakravorty R N
J Neurol Sci. 1977 May;32(1):53-67. doi: 10.1016/0022-510x(77)90039-9.
Structural changes have been studied in peripheral nerves in streptozotocin-induced diabetic monkeys. Teased single nerve fibre preparations were most informative. Abnormalities were present in 32 of 58 nerves examined from 15 diabetic monkeys with varying degree of hyperglycaemia. The earliest change was an increase in the gap at nodes of Ranvier, seen 12 weeks after the diabetic state had been established. Well marked segmental demyelination was seen in distal nerves at 14-16 weeks. Later similar changes were seen in proximal, larger nerves. Evidence of remyelination was present at a later date. Wallerian degneration was seen in only 4 nerves. Changes in the myelin sheath were more prominant than axonal abnormalities at all times. There was no abnormality in the vasa nervorum and only a mild increase in endoneurial and perineurial fibrous tissue. A direct correlation was present between the extent and degree of pathology and both severity as well as duration of hyperglycaemia.
已经对链脲佐菌素诱导的糖尿病猴的外周神经结构变化进行了研究。 teased单神经纤维制剂最具信息性。在15只患有不同程度高血糖的糖尿病猴检查的58条神经中，有32条存在异常。最早的变化是在糖尿病状态确立12周后，郎飞结处的间隙增加。在14 - 16周时，在远端神经中可见明显的节段性脱髓鞘。后来在近端较大的神经中也出现了类似的变化。后期有髓鞘再生的证据。仅在4条神经中观察到华勒氏变性。在所有时间点，髓鞘的变化都比轴突异常更明显。神经血管无异常，神经内膜和神经束膜纤维组织仅轻度增加。病理学的范围和程度与高血糖的严重程度和持续时间之间存在直接相关性。
