Mattingly G E, Fischer V W
Acta Neuropathol. 1983;59(2):133-8. doi: 10.1007/BF00691599.
An experimental diabetic state was induced in rats by means of an injection of streptozotocin. A histological and histometric evaluation of randomly teased nerve fibers was applied to the common peroneal nerves of both diabetic and age- and weight-matched control rats. A long-term (6-12 months) exposure to the diabetic state was required for the demonstration of the following morphological changes: (1) splitting and notching of myelin sheaths, (2) decrease in the ratio of internodal length/internodal diameter, (3) widening of nodal gaps. This study showed that neurons of smaller caliber are preferentially affected after a prolonged period of the diabetic condition. Neurons of this size are representative of sensory and autonomic components, suggesting that the changes present in this model parallel the derangements of these constituents reported in the human diabetic with adult onset disease.
通过注射链脲佐菌素在大鼠中诱导出实验性糖尿病状态。对糖尿病大鼠以及年龄和体重匹配的对照大鼠的腓总神经进行了随机分离神经纤维的组织学和组织测量学评估。为了证明以下形态学变化，需要长期（6 - 12个月）处于糖尿病状态：（1）髓鞘的分裂和缺口，（2）节间长度/节间直径比值降低，（3）结间隙增宽。这项研究表明，在糖尿病状态持续较长时间后，较小直径的神经元更容易受到影响。这种大小的神经元代表感觉和自主神经成分，这表明该模型中出现的变化与成年发病型人类糖尿病中这些成分的紊乱情况相似。
