咪唑并[2,1-b]噻唑腈、酰胺及对磺酰胺基苯腙的合成与药理活性
Synthesis and pharmacological activity of imidazo [2,1-b] thiazole nitriles, amides and p-sulfamidophenylhydrazones.
作者信息
Andreani A, Rambaldi M, Locatelli A, Pifferi G, Malandrino S
机构信息
Dipartimento di Scienze Farmaceutiche, University of Bologna, Italy.
出版信息
Pharm Acta Helv. 1992;67(7):195-7.
PMID:1409757
Abstract
The synthesis of three series of new imidazo [2,1-b] thiazoles (nitriles 1-7, amides 8-14 and p-sulfamidophenylhydrazones 15-24) is reported. Among the compounds tested, only 12 showed a borderline diuretic activity. Compounds 15-24, possible prodrugs of sulfanilamide, were devoid of antibacterial activity.
摘要
报道了三个系列新型咪唑并[2,1 - b]噻唑（腈类1 - 7、酰胺类8 - 14和对磺酰胺基苯腙类15 - 24）的合成。在所测试的化合物中，只有12显示出临界利尿活性。化合物15 - 24可能是磺胺的前药，没有抗菌活性。
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