Synthesis of imidazo[2,1-b]thiazoles and thiazolines as potential antiulcer agents.
作者信息
Andreani A, Rambaldi M, Leoni A, Locatelli A, Pifferi G
机构信息
Dipartimento di Scienze Farmaceutiche, Università di Bologna, Italy.
出版信息
J Pharm Belg. 1994 Jul-Aug;49(4):308-14.
PMID:7965580
Abstract
The replacement of the imidazole ring of cimetidine with a bicyclic system (imidazo[1,2-a]pyridine), reported in the literature, produced compounds endowed with potent antiulcer activity. In this paper we describe the synthesis of imidazo [2,1-b]thiazoles and thiazolines bearing the side chain of metiamide, cimetidine and ranitidine: the compounds obtained, tested on gastric lesions induced in rats by ethanol and by stress, were devoid of antiulcer activity.
摘要
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