Segal D S, Kuczenski R, Okuda C
Department of Psychiatry, University of California, San Diego, La Jolla 92093-0603.
Pharmacol Biochem Behav. 1992 Jul;42(3):421-9. doi: 10.1016/0091-3057(92)90135-3.
Microdialysis was used in behaving rats to further characterize the behavioral and regional dopamine (DA) response to the monoamine oxidase (MAO) inhibitor clorgyline and determine how MAO inhibition affects amphetamine (AMPH)-induced changes in behavioral and extracellular DA dynamics. Although clorgyline (4.0 mg/kg) did not significantly alter behavior, it produced prolonged increases in caudate and accumbens extracellular DA and 3MT and corresponding decreases in homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC). Clorgyline pretreatment altered the behavioral response to both low (0.25 mg/kg) and moderate (2.5 mg/kg) doses of AMPH, which was characterized by a shift to more intense forms of stereotype and corresponding decreases in locomotion. The caudate and accumbens DA response to AMPH (0.25 mg/kg) was also significantly augmented, consistent with an increase in AMPH-releasable cytoplasmic DA. Thus, the potentiated DA response in clorgyline-pretreated animals may be responsible for the changes in the stereotypy profile. Possible implications of these observations for the augmented behavioral response observed with repeated AMPH administration are discussed.
在行为学实验大鼠中采用微透析技术，进一步明确单胺氧化酶（MAO）抑制剂氯吉兰对行为和脑区多巴胺（DA）反应的特征，并确定MAO抑制如何影响苯丙胺（AMPH）诱导的行为和细胞外DA动力学变化。尽管氯吉兰（4.0mg/kg）未显著改变行为，但它使尾状核和伏隔核细胞外DA和3-甲氧基酪胺（3MT）持续增加，同时使高香草酸（HVA）和二羟基苯乙酸（DOPAC）相应减少。氯吉兰预处理改变了对低剂量（0.25mg/kg）和中等剂量（2.5mg/kg）AMPH的行为反应，表现为刻板行为形式转变为更强烈类型，同时运动减少。尾状核和伏隔核对AMPH（0.25mg/kg）的DA反应也显著增强，这与可被AMPH释放的胞质DA增加一致。因此，氯吉兰预处理动物中增强的DA反应可能是刻板行为特征变化的原因。讨论了这些观察结果对于重复给予AMPH所观察到的增强行为反应的可能意义。
