Deutsch S I, Norris D O, O'Connor D A, Mastropaolo J
Psychiatry Service, Department of Veterans Affairs Medical Center, Washington, DC 20422.
Pharmacol Biochem Behav. 1992 Jul;42(3):517-8. doi: 10.1016/0091-3057(92)90147-8.
Cold water swim stress has been shown to decrease the ability of flurazepam, a prototypic GABA-positive benzodiazepine, to antagonize the electrical precipitation of seizures in mice. This stress-induced reduction in the antiseizure efficacy of flurazepam is not due to a reduction in the threshold voltage for seizure production. In this study, we examined the effect of treating mice with flurazepam 20 min prior to cold water swim stress on its ability to antagonize electrically precipitated seizures 24 h later. Contrary to our expectation, pretreatment with flurazepam potentiated the stress-induced reduction of its antiseizure efficacy.
冷水游泳应激已被证明会降低原型GABA阳性苯二氮䓬类药物氟西泮拮抗小鼠癫痫电惊厥的能力。这种应激诱导的氟西泮抗癫痫疗效降低并非由于癫痫发作产生的阈值电压降低。在本研究中，我们检测了在冷水游泳应激前20分钟用氟西泮处理小鼠对其24小时后拮抗电惊厥发作能力的影响。与我们的预期相反，氟西泮预处理增强了应激诱导的其抗癫痫疗效降低。
