Rosse R B, Mastropaolo J, Novitzki M R, Deutsch S I
Psychiatry Service, Veterans Administration Medical Center, Washington, D.C. 20422.
Psychoneuroendocrinology. 1990;15(1):83-5. doi: 10.1016/0306-4530(90)90050-j.
We examined whether pretreatment with depot testosterone produces a functional alteration in benzodiazepine receptor sensitivity. This was accomplished by testing the ability of flurazepam to increase the threshold voltage for seizure production in groups of mice given vehicle or testosterone cypionate (1 or 5 mg/kg) 21 days prior to testing in an electroconvulsive shock paradigm. Depot testosterone treatment reduced flurazepam's antiseizure potency in this paradigm. That testosterone altered the ability of flurazepam to protect mice from seizures is consistent with previous reports suggesting a complex interaction between steroids and the BDZ/GABAA system.
我们研究了长效睾酮预处理是否会引起苯二氮䓬受体敏感性的功能性改变。这是通过在电休克范式测试前21天，给小鼠注射赋形剂或环戊丙酸睾酮（1或5毫克/千克），然后检测氟西泮提高癫痫发作阈值电压的能力来实现的。在该范式中，长效睾酮治疗降低了氟西泮的抗癫痫效力。睾酮改变氟西泮保护小鼠免受癫痫发作的能力，这与之前表明类固醇与BDZ/GABAA系统之间存在复杂相互作用的报道一致。
