ZILBER L A, BAJDAKOVA Z L, GARDASJAN A N, KONOVALOV N V, BUNINA T L, BARABADZE E M
Bull World Health Organ. 1963;29(4):449-56.
Although various hypotheses have been put out as to the etiology of amyotrophic lateral sclerosis, they do not seem to date to have been substantiated by experimental evidence. As the incidental outcome of studies on possible carcinogenic processes, the authors of this paper have obtained experimental data indicating the possibility of reproducing amyotrophic lateral sclerosis in monkeys by administering extracts from the spinal cord of persons who have died of the disease. The illness in monkeys is marked by a long incubation period, which may be of five years or more, and it is very similar to the disease in man in its clinical and pathological picture. The experimental evidence strongly suggests that this disease is of virus origin. The virus-like agent discovered has been passaged twice in monkeys without consequent attenuation; it is not pathogenic for mice and other laboratory animals.The authors point out that, before final conclusions can be drawn, serological and immunological confirmation is required. Research is now proceeding to that end.
尽管关于肌萎缩侧索硬化症的病因已经提出了各种假说，但迄今为止，它们似乎尚未得到实验证据的证实。作为对可能致癌过程研究的偶然结果，本文作者获得了实验数据，表明通过给死于该病的人的脊髓提取物，有可能在猴子身上重现肌萎缩侧索硬化症。猴子的这种疾病潜伏期很长，可能长达五年或更久，其临床和病理表现与人类疾病非常相似。实验证据有力地表明，这种疾病起源于病毒。所发现的类病毒因子已在猴子身上传代两次，并未因此而减弱毒性；它对小鼠和其他实验动物没有致病性。作者指出，在得出最终结论之前，需要进行血清学和免疫学确认。目前正在为此进行研究。
