Gall M A, Rossing P, Hommel E, Voldsgaard A I, Andersen P, Nielsen F S, Dyerberg J, Parving H H
Steno Memorial and Hvidöre Hospital, Klampenborg, Denmark.
Scand J Clin Lab Invest. 1992 Oct;52(6):513-21. doi: 10.3109/00365519209090129.
Insulin-dependent diabetic patients with diabetic nephropathy have a highly increased morbidity and mortality from cardiovascular diseases. To determine whether altered levels of apolipoprotein(a) (apo(a)), the glycoprotein of the potentially atherogenic lipoprotein(a) (Lp(a)), contribute to the increased risk of ischaemic heart disease, apo(a) was determined in 50 insulin-dependent diabetic patients with diabetic nephropathy (group 1), in 50 insulin-dependent diabetic patients with microalbuminuria (group 2), in 50 insulin-dependent diabetic patients with normoalbuminuria (group 3), and in 50 healthy subjects (group 4). The groups were matched with regard to sex, age and body mass index. The diabetic groups were also matched with regard to diabetes duration. The level of apo(a) was approximately the same in the four groups, being: 122 (x/ divided by 4.2) U l-1, 63 (x/ divided by 4.4) U l-1, 128 (x/ divided by 3.5) U l-1 and 126 (x/ divided by 3.7) U l-1 (geometric mean (x/ divided by antilog SD)) in group 1, 2, 3 and 4, respectively. 1 U l-1 apo(a) approximates 0.7 mg l-1 Lp(a).(ABSTRACT TRUNCATED AT 250 WORDS)
患有糖尿病肾病的胰岛素依赖型糖尿病患者心血管疾病的发病率和死亡率大幅增加。为了确定潜在致动脉粥样硬化性脂蛋白(a) [Lp(a)]的糖蛋白载脂蛋白(a) [apo(a)]水平的改变是否会增加缺血性心脏病的风险，对50名患有糖尿病肾病的胰岛素依赖型糖尿病患者（第1组）、50名患有微量白蛋白尿的胰岛素依赖型糖尿病患者（第2组）、50名患有正常白蛋白尿的胰岛素依赖型糖尿病患者（第3组）和50名健康受试者（第4组）进行了apo(a)测定。这些组在性别、年龄和体重指数方面进行了匹配。糖尿病组在糖尿病病程方面也进行了匹配。四组中的apo(a)水平大致相同，第1组、第2组、第3组和第4组分别为：122（几何均值（x/除以反对数标准差））U l-1、63（x/除以4.4）U l-1、128（x/除以3.5）U l-1和126（x/除以3.7）U l-1。1 U l-1 apo(a)约等于？？？0.7 mg l-1 Lp(a)。（摘要截短于250字） （注：原文中“1 U l-1 apo(a) approximates 0.7 mg l-1 Lp(a).”这里前面的“？？？”部分原文可能有误，不太明确准确内容）
