糖尿病视网膜病变患者的脂蛋白(a)血清水平。
Lipoprotein(a) serum levels in diabetic patients with retinopathy.
机构信息
International Ph D Program in Neuropharmacology, University of Catania, 95123 Catania, Italy.
出版信息
Biomed Res Int. 2013;2013:943505. doi: 10.1155/2013/943505. Epub 2013 Jun 5.
BACKGROUND
Atherogenic lipoproteins, such as total cholesterol, LDL cholesterol, oxidized low density lipoprotein, and triglycerides, are associated with progression of retinopathy. Aim. To evaluate the relationship between lipoprotein(a) and retinopathy in patients with type 2 diabetes mellitus.
MATERIALS AND METHODS
We enrolled 145 diabetic consecutive patients (82 females, 63 males; mean age 66.8 ± 12 years, mean duration of diabetes 9.4 ± 6.8 years). Presence and severity of retinopathy were evaluated. Serum lipid profile, including Lp(a) level, was assessed.
RESULTS
High Lp(a) levels have been observed in 54 (78.3%) subjects and normal levels in 13 (18.85%) subjects as regards diabetic patients with retinopathy. Lp(a) levels were high in 15 subjects (21.75%) and normal in 63 subjects (91.35%) as regards patients without retinopathy.
CONCLUSIONS
Lp(a) levels are increased in a significant percentage of patients with retinopathy compared to diabetic patients without retinopathy. The impact of Lp(a) levels on diabetic retinopathy needs to be further investigated.
背景
致动脉粥样硬化脂蛋白，如总胆固醇、LDL 胆固醇、氧化型低密度脂蛋白和甘油三酯，与视网膜病变的进展有关。目的。评估 2 型糖尿病患者脂蛋白(a)与视网膜病变的关系。
材料和方法
我们招募了 145 例连续的糖尿病患者（82 名女性，63 名男性；平均年龄 66.8 ± 12 岁，糖尿病病程 9.4 ± 6.8 年）。评估视网膜病变的存在和严重程度。评估血清脂质谱，包括脂蛋白(a)水平。
结果
患有视网膜病变的糖尿病患者中，54 例（78.3%）脂蛋白(a)水平升高，13 例（18.85%）脂蛋白(a)水平正常。无视网膜病变的患者中，15 例（21.75%）脂蛋白(a)水平升高，63 例（91.35%）脂蛋白(a)水平正常。
结论
与无视网膜病变的糖尿病患者相比，脂蛋白(a)水平升高的患者中视网膜病变的比例显著增加。脂蛋白(a)水平对糖尿病性视网膜病变的影响需要进一步研究。
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