Curtsinger J W, Fukui H H, Townsend D R, Vaupel J W
Department of Ecology, Evolution, and Behavior, University of Minnesota, Minneapolis 55455.
Science. 1992 Oct 16;258(5081):461-3. doi: 10.1126/science.1411541.
Experimental systems that are amenable to genetic manipulation can be used to address fundamental questions about genetic and nongenetic determinants of longevity. Analysis of large cohorts of ten genotypes of Drosophila melanogaster raised under conditions that favored extended survival has revealed variation between genotypes in both the slope and location of age-specific mortality curves. More detailed examination of a single genotype showed that the mortality trajectory was best fit by a two-stage Gompertz model, with no age-specific increase in mortality rates beyond 30 days after emergence. These results are contrary to the limited life-span paradigm, which postulates well-defined, genotype-specific limits on life-span and brief periods of intense and rapidly accelerating mortality rates at the oldest age.
适合基因操作的实验系统可用于解决有关寿命的遗传和非遗传决定因素的基本问题。对在有利于延长生存期的条件下饲养的十个黑腹果蝇基因型的大量群体进行分析后发现，特定年龄死亡率曲线的斜率和位置在不同基因型之间存在差异。对单一基因型进行更详细的检查表明，死亡率轨迹最适合用两阶段冈珀茨模型来拟合，即羽化后30天以上死亡率没有特定年龄的增加。这些结果与有限寿命范式相反，该范式假定寿命有明确的、特定基因型的限制，并且在最高龄时有短暂的高强度和快速加速的死亡率时期。
