DUKES C E
Can Med Assoc J. 1964 Mar 7;90(10):630-5.
The early diagnosis and treatment of precancerous lesions is an important means of control of intestinal cancer. The precancerous tendency is relatively slight with solitary colo-rectal polyps, ulcerative colitis and bilharzial infestation, but it is exceptionally severe in familial colonic polyposis.For more than 30 years, research into the inheritance and treatment of familial polyposis has been continued at St. Mark's Hospital, London, England, and more than 90 families have been investigated and family pedigrees prepared. These now include 1050 "members", of whom 343 have had either polyposis or intestinal cancer, or both, the number with cancer being 243. One hundred and one of these 343 patients have been operated on at St. Mark's, 61 undergoing colectomy and ileorectal anastomosis.Cancer control is achieved by keeping under supervision all members of a family who have already developed polyposis or who may do so later.
癌前病变的早期诊断和治疗是控制肠癌的重要手段。孤立性结直肠息肉、溃疡性结肠炎和血吸虫感染的癌前倾向相对较轻，但在家族性结肠息肉病中则异常严重。30多年来，英国伦敦圣马克医院一直在持续开展家族性息肉病的遗传和治疗研究，已对90多个家庭进行了调查并绘制了家族谱系。这些家族谱系现在包括1050名“成员”，其中343人患有息肉病或肠癌，或两者皆有，患癌人数为243人。这343名患者中有101人在圣马克医院接受了手术，61人接受了结肠切除术和回肠直肠吻合术。通过对所有已患息肉病或以后可能患息肉病的家庭成员进行监测来实现癌症控制。
