Poulet F M, Valentine B A, Summers B A
Department of Pathology, New York State College of Veterinary Medicine, Cornell University, Ithaca.
Vet Pathol. 1992 Sep;29(5):369-80. doi: 10.1177/030098589202900501.
A retrospective histologic study of 12 canine and eight feline epithelial odontogenic tumors and cysts was conducted from oral masses (n = 3,917) obtained between 1980 and 1990. No sex or breed predilection was identified. Ameloblastoma was observed in two dogs (case Nos. 1, 2) 6 and 8 months of age. Calcifying epithelial odontogenic tumors were seen in a dog (case No. 3) and in two cats (case Nos. 4, 5) between 8 and 16 years of age. Ameloblastic fibroma (or fibroameloblastoma) was observed in cats (case Nos. 6-10) only. Inductive fibroameloblastoma was observed in four cats (case Nos. 6-9) up to 1 year of age, whereas ameloblastic fibroma was seen in a 14-year-old cat (case No. 10). A single ameloblastic odontoma was identified in a 20-month-old dog (case No. 11). Two complex odontomas occurred in a 6-month-old (case No. 12) and a 4-year-old (case No. 13) dog. Odontogenic cysts were identified in five dogs (case Nos. 14-18) aged 4.5 months to 16 years and in a 1-year-old cat (case No. 19) and have not been previously reported in these species. These cysts were lined by a stratified epithelium reminiscent of the appearance of ameloblastic epithelium. An odontogenic keratocyst with prominent central parakeratotic keratinization was identified in one 9-year-old female dog (case No. 20). Almost all epithelial odontogenic tumors were circumscribed, benign tumors that warranted a good prognosis for survival, although local recurrence may have followed (or may follow) incomplete excision. Calcifying epithelial odontogenic tumors may be locally invasive. Of six odontogenic cysts (case Nos. 14-19), two (case Nos. 15, 18) gave rise to basi-squamous carcinomas. The classification and behavior of epithelial odontogenic tumors and cysts in human beings, dogs, and cats are discussed.
对1980年至1990年间获取的3917例口腔肿物进行回顾性组织学研究，其中包括12例犬和8例猫的上皮性牙源性肿瘤及囊肿。未发现性别或品种偏好。在2只6月龄和8月龄的犬（病例编号1、2）中观察到成釉细胞瘤。在1只8至16岁的犬（病例编号3）以及2只8至16岁的猫（病例编号4、5）中发现钙化上皮性牙源性肿瘤。成釉细胞纤维瘤（或纤维成釉细胞瘤）仅在猫（病例编号6 - 10）中观察到。诱导性成釉细胞纤维瘤在4只1岁以下的猫（病例编号6 - 9）中观察到，而成釉细胞纤维瘤在1只14岁的猫（病例编号10）中发现。在1只20月龄的犬（病例编号11）中鉴定出1例单发性成釉细胞牙瘤。2例复合性牙瘤分别发生在1只6月龄（病例编号12）和1只4岁（病例编号13）的犬中。在5只4.5月龄至16岁的犬（病例编号14 - 18）以及1只1岁的猫（病例编号19）中鉴定出牙源性囊肿，这些囊肿在这些物种中此前未见报道。这些囊肿内衬复层上皮，类似于成釉细胞上皮的外观。在1只9岁雌性犬（病例编号20）中鉴定出具有显著中央不全角化的牙源性角化囊肿。几乎所有上皮性牙源性肿瘤均为边界清晰的良性肿瘤，预后生存良好，尽管不完全切除后可能（或可能会）出现局部复发。钙化上皮性牙源性肿瘤可能具有局部侵袭性。在6例牙源性囊肿（病例编号14 - 19）中，2例（病例编号15、18）发展为基底鳞状细胞癌。讨论了人类、犬和猫上皮性牙源性肿瘤及囊肿的分类和行为。
