Vandewoude M F, Buyssens N
Department of Geriatrics, University of Antwerp, Belgium.
Virchows Arch A Pathol Anat Histopathol. 1992;421(3):189-92. doi: 10.1007/BF01611174.
The modulating effects of ageing and malnutrition on rat myocardium were studied morphometrically with respect to the microvasculature. An increase in capillary density together with a decrease in capillary lumen cross-sectional area was noted during starvation. The important changes seen in the myocyte T-system were paralleled by a decreased diffusion distance for oxygen from the capillary lumen to the mitochondrion. The changes described in the aged rat heart point to an altered inter-relationship between parenchyma and vascularization with a lower capillary volume fraction and a greater diffusion distance from the capillary lumen to the mitochondrion; this is caused by hypertrophy of the aged myocyte. This reduction in capacity to exchange substrates is further reduced by the less developed T-system in the older myocyte.
从微血管形态计量学方面研究了衰老和营养不良对大鼠心肌的调节作用。饥饿期间发现毛细血管密度增加，同时毛细血管腔横截面积减小。心肌细胞T系统出现的重要变化与从毛细血管腔到线粒体的氧扩散距离缩短相一致。老年大鼠心脏中所描述的变化表明实质与血管形成之间的相互关系发生了改变，毛细血管体积分数降低，从毛细血管腔到线粒体的扩散距离增大；这是由老年心肌细胞肥大引起的。老年心肌细胞中发育较差的T系统进一步降低了底物交换能力。
