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[使用ω-3多不饱和脂肪酸治疗高血压和缺血性心脏病时的脂质过氧化作用]

[Lipid peroxidation upon the use of omega-3 polyunsaturated fatty acids in the treatment of hypertension and ischemic heart disease].

作者信息

Karagodina Z V, Korf I I, L'vovich N A, Abbakumov A S, Pogozheva A V, Levachev M M

出版信息

Vopr Med Khim. 1992 May-Jun;38(3):20-2.

PMID:1413641
Abstract

Anti-atherosclerotic diet containing 10 or 20 g of ichthyenic oil, used for treatment of 29 patients with cardiovascular diseases, caused an increase in content of polyunsaturated omega 3 fatty acids species in the patients erythrocyte membranes; this pattern may be used as a sensitive criterion of evaluation of the diet fatty component effect. Despite an increase of oxidation potential substrates in tissues, elevation of malonyl dialdehyde in blood plasma and hemolysis of erythrocytes in presence of H2O2 were not observed. This suggests absence of lipid peroxidation induction in adequate consumption of antioxidants.

摘要

含10克或20克鱼油的抗动脉粥样硬化饮食用于治疗29例心血管疾病患者,可使患者红细胞膜中多不饱和ω-3脂肪酸种类的含量增加;这种模式可作为评估饮食脂肪成分效果的敏感标准。尽管组织中氧化电位底物增加,但未观察到血浆中丙二醛升高以及在过氧化氢存在下红细胞溶血。这表明在适量摄入抗氧化剂时不会诱导脂质过氧化。

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Vopr Med Khim. 1992 May-Jun;38(3):20-2.
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