Vasil'ev A V, Biiasheva I R, Pokrovskaia G R, Mal'tsev G Iu, Varsanovich E A, Orlova L A, Soto S Kh
Vopr Med Khim. 1994 May-Jun;40(3):53-6.
A state of the anti-oxidation system in blood and the rate of lipid peroxidation were studied in patients with hypertension. High sensitivity of the anti-oxidation system enzymes to alterations in the diet fat composition was detected in the patients, nutrition of whom was evaluated in detail. Excessive doses of alpha-tocopherol, added to the diet enriched with omega 3-polyunsaturated fatty acids normalized lipid peroxidation and stabilized the enzyme activity involved in the anti-oxidation system. The integral parameter, proposed for evaluation of the anti-oxidation protection state and designated as "anti-oxidation index" involved estimation of catalase, superoxide dismutase, glutathione reductase and peroxidase activities as well as of content of malonic dialdehyde and diene conjugates in erythrocytes.
对高血压患者血液中的抗氧化系统状态和脂质过氧化速率进行了研究。在对饮食脂肪组成变化的抗氧化系统酶具有高敏感性的患者中，对其营养状况进行了详细评估。在富含ω-3多不饱和脂肪酸的饮食中添加过量的α-生育酚可使脂质过氧化正常化，并稳定抗氧化系统中涉及的酶活性。为评估抗氧化保护状态而提出的综合参数，称为“抗氧化指数”，涉及对过氧化氢酶、超氧化物歧化酶、谷胱甘肽还原酶和过氧化物酶活性以及红细胞中丙二醛和二烯共轭物含量的估计。
