细菌O抗原的结构与功能关系。III. 类毒素的生物学特性。
RELATIONSHIP OF STRUCTURE TO FUNCTION IN BACTERIAL O ANTIGENS. III. BIOLOGICAL PROPERTIES OF ENDOTOXOIDS.
作者信息
JOHNSON A G, NOWOTNY A
出版信息
J Bacteriol. 1964 Apr;87(4):809-14. doi: 10.1128/jb.87.4.809-814.1964.
Abstract
Johnson, Arthur G. (The University of Michigan, Ann Arbor), and Alois Nowotny. Relationship of structure to function in bacterial O antigens. III. Biological properties of endotoxoids. J. Bacteriol. 87:809-814. 1964.-Endotoxin (somatic O antigen) was rendered much less lethal for mice and rabbits after treatment with boron trifluoride, potassium methylate, or pyridinium formate. In addition, the ability to induce the second fever peak of the biphasic febrile response characteristic of endotoxin was abolished. The capacity to prepare for the local Shwartzman reaction was also reduced after such treatments. On the other hand, stimulation of nonspecific resistance, and adjuvant action in mice was retained. The ability to elicit specific antibody was diminished after boron trifluoride treatment but only slightly retarded by the other two procedures.
摘要
约翰逊，亚瑟·G.（密歇根大学，安阿伯分校），以及阿洛伊斯·诺沃特尼。细菌O抗原结构与功能的关系。III.类毒素的生物学特性。《细菌学杂志》87:809 - 814。1964年。——用三氟化硼、甲醇钾或甲酸吡啶处理后，内毒素（菌体O抗原）对小鼠和兔子的致死性大大降低。此外，诱导内毒素特征性双相热反应第二个发热高峰的能力被消除。经此类处理后，引发局部施瓦茨曼反应的能力也降低了。另一方面，对非特异性抵抗力的刺激以及在小鼠中的佐剂作用得以保留。经三氟化硼处理后引发特异性抗体的能力减弱，但另外两种处理方式只是使其稍有延迟。
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