Franzl R E, McMaster P D
J Exp Med. 1968 Jun 1;127(6):1087-107. doi: 10.1084/jem.127.6.1087.
The manner in which a single injection of S. typhosa endotoxin effects the primary hemolysin response to sheep erythrocytes in the mouse has been shown to depend on the dosage, route, and time of administration of the endotoxin, as well as on the route employed for the injection of antigen. The normal production of antibody, following an intravenous or an intraperitoneal injection of red blood cells, is suppressed if the bacterial lipopolysaccharide is given before and by the same route as the antigen. The response to an intraperitoneal injection of sheep red cells is also inhibited if preceded by an intravenous injection of endotoxin. By contrast, hemolysin formation to intravenous antigen is enhanced considerably by a previous intraperitoneal injection of endotoxin, and the response both to intravenous and to intraperitoneal injections of the antigen increases if the endotoxin is given by the same route either simultaneously or shortly after the foreign red cells. These findings are discussed in regard to the physiological action of bacterial endotoxins and the early events in antibody formation.
已表明，单次注射伤寒沙门氏菌内毒素影响小鼠对绵羊红细胞的初次溶血素反应的方式取决于内毒素的剂量、给药途径和时间，以及注射抗原所采用的途径。如果在静脉内或腹腔内注射红细胞后以与抗原相同的途径预先给予细菌脂多糖，则抗体的正常产生会受到抑制。如果在腹腔内注射绵羊红细胞之前先静脉内注射内毒素，其反应也会受到抑制。相比之下，先前腹腔内注射内毒素会显著增强对静脉内抗原的溶血素形成，并且如果内毒素与外来红细胞同时或以相同途径在其之后不久给予，则对静脉内和腹腔内注射抗原的反应都会增加。就细菌内毒素的生理作用和抗体形成的早期事件对这些发现进行了讨论。
