Van Damme B J, Fleuren G J, Bakker W W, Vernier R L, Hoedemaeker P J
Lab Invest. 1978 Apr;38(4):502-10.
In heterologous immune complex glomerulonephritis glomerular deposition of immune complexes occurs immediately after an injection with heterologous antibody directed against antigen, derived from the brush border of the tubules. The injected antibody is thought to combine with circulating Fx1A antigen to form immune complexes which subsequently are deposited in the glomeruli. However, perfusion of rat kidneys in absence of this antigen likewise resulted in prompt localization of immune complexes along the glomerular basement membrane. Further, Fx1A antigen was shown to be present in the capillary wall, especially in the filtration slits and on the cell membrane of epithelial cells. From these findings it was concluded that in this model of glomerulonephritis the deposited immune complexes are formed locally instead of being deposited from the circulation. This concept of "fixed antigen" may also be relevant to the pathogenesis of other forms of experimental glomerulonephritis and probably also for human glomerulonephritis.
在异种免疫复合物性肾小球肾炎中，注射针对源自肾小管刷状缘抗原的异种抗体后，免疫复合物会立即在肾小球沉积。注入的抗体被认为与循环中的Fx1A抗原结合形成免疫复合物，随后这些复合物沉积在肾小球中。然而，在没有这种抗原的情况下对大鼠肾脏进行灌注，同样会导致免疫复合物迅速沿肾小球基底膜定位。此外，已证明Fx1A抗原存在于毛细血管壁，尤其是在滤过裂隙和上皮细胞的细胞膜上。从这些发现得出的结论是，在这种肾小球肾炎模型中，沉积的免疫复合物是在局部形成的，而不是从循环中沉积而来。这种“固定抗原”的概念可能也与其他形式的实验性肾小球肾炎的发病机制相关，并且可能对人类肾小球肾炎也适用。
