肥胖和非肥胖小鼠肝脏中的柠檬酸裂解酶
CITRATE CLEAVAGE ENZYME IN LIVERS OF OBESE AND NONOBESE MICE.
作者信息
KORNACKER M S, LOWENSTEIN J M
出版信息
Science. 1964 May 22;144(3621):1027-8. doi: 10.1126/science.144.3621.1027.
Abstract
The specific activity of the citrate cleavage enzyme is 3.3 times greater in livers of obese mice than in livers of their nonobese litter mates. The difference persists during starvation. The specific activity of the acetate activating enzyme is approximately the same in the livers of both types of animals. It is proposed that a high activity of citrate cleavage enzyme is one of the factors responsible for obesity.
摘要
肥胖小鼠肝脏中柠檬酸裂解酶的比活性比其非肥胖同窝小鼠肝脏中的比活性高3.3倍。这种差异在饥饿期间持续存在。两种动物肝脏中乙酸激活酶的比活性大致相同。有人提出，柠檬酸裂解酶的高活性是导致肥胖的因素之一。
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