肥胖高血糖小鼠（ob/ob）肝脏和脂肪组织中硬脂酸的去饱和作用
Desaturation of stearic acid by liver and adipose tissue from obese-hyperglycaemic mice (ob/ob).
作者信息
Enser M
出版信息
Biochem J. 1975 Jun;148(3):551-5. doi: 10.1042/bj1480551.
Abstract
Stearic acid desaturase activity was assayed in preparations from perigenital adipose tissue and liver from lean and genetically obese female mice (ob/ob). The total activity in the perigenital adipose tissue from obese mice was threefold greater than in the tissue from lean mice, but per g of adipose tissue the activity was twofold greater in tissue from lean mice. In liver, the activity in obese mice was elevated at 8 weeks of age, remained elevated up to 24 weeks and then decreased by half at 48 weeks, but at all ages was higher than that in lean mice. The decrease in desaturase activity of liver from obese mice at 48 weeks corresponded to a change in the fatty acid composition of liver lipids toward that found in lean mice. Whereas in adipose tissue much of the increased enzyme activity may be due to tissue hyperplasia, in liver it is mainly an increased activity per cell.
摘要
对来自瘦型和遗传性肥胖雌性小鼠（ob/ob）的生殖器周围脂肪组织及肝脏的提取物进行了硬脂酸去饱和酶活性测定。肥胖小鼠生殖器周围脂肪组织中的总活性比瘦型小鼠组织中的高两倍，但每克脂肪组织中，瘦型小鼠组织中的活性高1倍。在肝脏中，肥胖小鼠的活性在8周龄时升高，直至24周龄一直保持升高，然后在48周龄时降低一半，但在所有年龄段均高于瘦型小鼠。肥胖小鼠肝脏在48周龄时去饱和酶活性的降低与肝脏脂质脂肪酸组成向瘦型小鼠的转变相对应。在脂肪组织中，酶活性增加的大部分原因可能是组织增生，而在肝脏中，主要是每个细胞的活性增加。
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