柠檬酸与碳水化合物向脂肪的转化。肥胖和哺乳期的柠檬酸裂解。
Citrate and the conversion of carbohydrate into fat. Citrate cleavage in obesity and lactation.
作者信息
Spencer A F, Lowenstein J M
出版信息
Biochem J. 1966 Jun;99(3):760-5. doi: 10.1042/bj0990760.
Abstract
- The specific activity of ATP citrate lyase is two to four times as great in livers of mice with hereditary obesity as in livers of their non-obese siblings. The enzyme activity in both types of mice can be reduced by starvation, and can be increased by refeeding starved animals. The specific activity of acetyl-CoA synthetase is approximately the same in both types of mice. 2. ATP citrate lyase of mammary gland of the rat undergoes large increases in activity after the onset of lactation. It declines rapidly upon weaning. 3. The changes in activity of ATP citrate lyase in obesity and lactation are consistent with the hypothesis that the enzyme supplies extramitochondrial acetyl-CoA for fatty acid synthesis.
摘要
- 遗传性肥胖小鼠肝脏中ATP柠檬酸裂解酶的比活性是非肥胖同胞小鼠肝脏的两到四倍。两种类型小鼠的酶活性均可通过饥饿降低，并可通过给饥饿动物重新喂食而增加。两种类型小鼠中乙酰辅酶A合成酶的比活性大致相同。2. 大鼠乳腺的ATP柠檬酸裂解酶在泌乳开始后活性大幅增加。断奶后迅速下降。3. ATP柠檬酸裂解酶在肥胖和泌乳过程中的活性变化与该酶为脂肪酸合成提供线粒体外乙酰辅酶A的假说一致。
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