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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Jurgens T M, Hufford C D, Clark A M

Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University 38677.

Xenobiotica. 1992 May;22(5):569-77. doi: 10.3109/00498259209053120.

A total of 114 microorganisms were evaluated for their ability to metabolize the antifungal drimane sesquiterpene, muzigadial. 2. Cryptococcus neoformans was found to convert muzigadial to one major metabolite, identified as a hemiacetal. 3. Streptomyces platensis produced three metabolites: the hemiacetal, its corresponding lactone, and the epoxide of the hemiacetal. 4. Streptomyces spectabilis produced the hemiacetal as well as the epoxy hemiacetal. 5. The proposed structures of all of the metabolites were based on comparisons of the spectroscopic data (1H- and 13C-n.m.r. spectra and mass spectra) between the metabolites and the parent compound. 6. Antimicrobial evaluation of the microbial metabolites indicate that metabolism decreases antifungal activity.

总共对114种微生物代谢抗真菌杜松烷倍半萜穆紫加迪醇的能力进行了评估。2. 发现新型隐球菌将穆紫加迪醇转化为一种主要代谢产物，鉴定为半缩醛。3. 普拉特链霉菌产生了三种代谢产物：半缩醛、其相应的内酯以及半缩醛的环氧化物。4. 壮观链霉菌产生了半缩醛以及环氧半缩醛。5. 所有代谢产物的推测结构均基于代谢产物与母体化合物之间光谱数据（1H和13C核磁共振光谱以及质谱）的比较。6. 对微生物代谢产物的抗菌评估表明，代谢作用会降低抗真菌活性。

Jurgens T M, Hufford C D, Clark A M

Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University 38677.

Xenobiotica. 1992 May;22(5):569-77. doi: 10.3109/00498259209053120.

A total of 114 microorganisms were evaluated for their ability to metabolize the antifungal drimane sesquiterpene, muzigadial. 2. Cryptococcus neoformans was found to convert muzigadial to one major metabolite, identified as a hemiacetal. 3. Streptomyces platensis produced three metabolites: the hemiacetal, its corresponding lactone, and the epoxide of the hemiacetal. 4. Streptomyces spectabilis produced the hemiacetal as well as the epoxy hemiacetal. 5. The proposed structures of all of the metabolites were based on comparisons of the spectroscopic data (1H- and 13C-n.m.r. spectra and mass spectra) between the metabolites and the parent compound. 6. Antimicrobial evaluation of the microbial metabolites indicate that metabolism decreases antifungal activity.

总共对114种微生物代谢抗真菌杜松烷倍半萜穆紫加迪醇的能力进行了评估。2. 发现新型隐球菌将穆紫加迪醇转化为一种主要代谢产物，鉴定为半缩醛。3. 普拉特链霉菌产生了三种代谢产物：半缩醛、其相应的内酯以及半缩醛的环氧化物。4. 壮观链霉菌产生了半缩醛以及环氧半缩醛。5. 所有代谢产物的推测结构均基于代谢产物与母体化合物之间光谱数据（1H和13C核磁共振光谱以及质谱）的比较。6. 对微生物代谢产物的抗菌评估表明，代谢作用会降低抗真菌活性。