Bocchetta A, Bernardi F, Burrai C, Pedditzi M, Loviselli A, Velluzzi F, Martino E, Del Zompo M
Department of Neurosciences B. B. Brodie, University of Cagliari, Italy.
Acta Psychiatr Scand. 1992 Jul;86(1):38-41. doi: 10.1111/j.1600-0447.1992.tb03222.x.
A total of 116 patients on lithium treatment were followed up for 2 years to determine the course and the clinical relevance of thyroid abnormalities. Elevated thyroid-stimulating hormone (TSH) concentrations were transitory in most patients, except those with serum antithyroid antibodies. The patients who initially had microsomal antibodies remained positive, with an increase in titre in two-thirds of cases. Three young patients of both sexes developed thyroid autoimmunity early in the treatment. The risk of developing hypothyroidism was higher in women, especially in the presence of antibodies. TSH concentrations were significantly lower when carbamazepine was combined with lithium.
对116名接受锂治疗的患者进行了为期2年的随访，以确定甲状腺异常的病程及临床相关性。除血清抗甲状腺抗体阳性的患者外，大多数患者促甲状腺激素（TSH）浓度升高是暂时的。最初有微粒体抗体的患者仍呈阳性，三分之二的病例滴度升高。三名年轻男女患者在治疗早期出现甲状腺自身免疫。女性发生甲状腺功能减退的风险更高，尤其是存在抗体时。当卡马西平与锂联合使用时，TSH浓度显著降低。
