迷走神经对犬心室的负性肌力作用。

NEGATIVE INOTROPIC EFFECT OF THE VAGUS NERVES UPON THE CANINE VENTRICLE.

作者信息

DEGEEST H, LEVY M N, ZIESKE H

出版信息

Science. 1964 Jun 5;144(3623):1223-5. doi: 10.1126/science.144.3623.1223.

DOI:10.1126/science.144.3623.1223

Abstract

In an innervated, paced, left heart preparation in which the left ventricle contracted against a constant volume of incompressible fluid (isovolumetric preparation), electrical stimulation of the distal end of either sectioned cervical vagus nerve decreased the peak tension generated by the teft ventricle. The vagi, therefore, exert a negative inotropic effect directly upon the ventricular myocardium.

摘要

在一个有神经支配、有起搏的左心制备模型中，左心室对抗恒定体积的不可压缩液体收缩（等容制备模型），电刺激切断的颈迷走神经任一分支的远端，可降低左心室产生的峰值张力。因此，迷走神经对心室心肌直接产生负性变力作用。