刺激狗、鸭和蟾蜍的迷走神经对心脏的变力作用。

The inotropic effect on the heart of stimulating the vagus in the dog, duck and toad.

作者信息

Furnival C M, Linden R J, Snow H M

出版信息

J Physiol. 1973 Apr;230(1):155-70. doi: 10.1113/jphysiol.1973.sp010180.

DOI:10.1113/jphysiol.1973.sp010180

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1350391/

Abstract

The chronotropic and inotropic effects of stimulating the vagus on the hearts of the dog, duck and toad were studied.2. The maximum rate of rise of pressure in the left ventricle (dP/dt max) measured at a constant heart rate and mean aortic pressure was used as an index of the inotropic changes.3. The sensitivity of dP/dt max as an index of inotropic changes brought about by stimulating the vagus was established in the toad where a 49% reduction in heart rate was associated with a 30% reduction in dP/dt max.4. In the dog stimulation of the vagus resulted in a reduction in heart rate of 38% and only a small reduction in dP/dt max of 6%.5. Results similar to those found in the dog were obtained in the duck where the reduction in heart rate of 44% was associated with reduction in dP/dt max of only 3%.6. It is concluded that the vagus has only a small and negligible negative inotropic effect on the ventricles of the dog and duck.

摘要

研究了刺激迷走神经对狗、鸭和蟾蜍心脏的变时性和变力性作用。
在恒定心率和平均主动脉压下测量的左心室压力最大上升速率（dP/dt max）被用作变力性变化的指标。
在蟾蜍中确定了dP/dt max作为刺激迷走神经引起的变力性变化指标的敏感性，心率降低49%与dP/dt max降低30%相关。
在狗中，刺激迷走神经导致心率降低38%，而dP/dt max仅小幅降低6%。
在鸭中获得了与狗相似的结果，心率降低44%仅与dP/dt max降低3%相关。
得出的结论是，迷走神经对狗和鸭的心室只有微小且可忽略不计的负性变力作用。