Kikendall J W, Glass A R, Sobin L H, Bowen P E
Department of Medicine, Walter Reed Army Medical Center, Washington, DC.
Am J Gastroenterol. 1992 Oct;87(10):1394-7.
Two previous studies have shown higher circulating gastrin levels in subjects with colonic neoplasia than in colonoscopy-negative controls. In this much larger study, sera were collected from fasting subjects undergoing colonoscopy. Colonoscopy with biopsy classified participants as having colonic adenomas (N = 139), colon carcinoma (N = 29), or controls without colonic neoplasia (N = 150). Frozen, stored sera were later analyzed for gastrin by radioimmunoassay. Serum gastrin values were no higher in subjects with colonic adenomas or carcinoma than in colonoscopy-negative controls. We conclude that elevated serum gastrin levels play little, if any, role in the initiation of colonic neoplasia.
此前的两项研究表明，患有结肠肿瘤的受试者体内胃泌素循环水平高于结肠镜检查阴性的对照组。在这项规模大得多的研究中，从接受结肠镜检查的空腹受试者中采集血清。通过活检的结肠镜检查将参与者分为患有结肠腺瘤（N = 139）、结肠癌（N = 29）或无结肠肿瘤的对照组（N = 150）。随后通过放射免疫分析法对冷冻保存的血清进行胃泌素分析。患有结肠腺瘤或癌的受试者的血清胃泌素值并不高于结肠镜检查阴性的对照组。我们得出结论，血清胃泌素水平升高在结肠肿瘤的发生中即便有作用，也微乎其微。
